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Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

The Division of Neuropsychiatry and Interventional Psychiatry at Mass General Brigham and Harvard Medical School is a clinical neuroscience division that integrates research and innovation (basic, translational, and clinical), clinical care (TMS, ECT, Ketamine, and Neuropsychiatry clinical services), and training (clinical and research fellowships, residents, and graduate students).
Receiving supervision from the Division Chief, the Senior Program/Project Manager will lead research operations for a large and dynamic research group with multiple grants, projects, and staff.
This role requires a professional with strong expertise in human research/clinical trials operations and working knowledge of research finance, able to serve as the operational backbone of the Division Chief’s portfolio while building infrastructure and systems that can be adopted by other investigators in the division.
The Senior Program Manager will serve as the primary operational partner to the Division Chief, coordinating closely with junior research staff and principal investigators/faculty in individual division labs, as well as with the department- and hospital-level pre- and post-award teams for research administration, ensuring a balance between centralized oversight and distributed implementation.

Qualifications

1. Human Research Operations & Team Leadership

Direct protocol development, regulatory compliance, study activation, and study execution across the Division Chief’s research portfolio.
Lead Study Management System Oversight, ensuring effective use of platforms such as OnCore or REDCap:
Protocol & Study Setup – Oversee the accurate documentation and activation of protocols and amendments.
Participant Management – Oversight of enrollment, consent, and visit scheduling.
Data Capture & Quality Control – Ensure timely and accurate data entry, integration with EHR/EDC systems.
Regulatory & Compliance Monitoring – Track IRB approvals, safety reporting, and maintain GCP-compliant audit trails.
Financial & Resource Tracking – Oversee study budgets, billing compliance, and resource allocation.
Reporting & Analytics – Generate real-time dashboards and reports for investigators and leadership.
Develop and enforce Standard Operating Procedures (SOPs) for research operations.
Provide training and mentorship to research staff to ensure high-quality, compliant study execution.
Oversee recruitment, onboarding, and professional development of research assistants and junior staff; serve as their administrative supervisor under a matrix reporting model.
Foster a positive, inclusive, and compliant workplace culture aligned with MGB and departmental values.

2. Grant Administration & Program Finances

Manage pre- and post-award activities for the Division Chief’s research portfolio, in close collaboration with hospital and departmental research management teams.
Serve as point person for grant submissions to MGB, NIH, and other funders; refine the submission pipeline by building efficient processes and templates.
Prepare, monitor, and update budgets, forecasts, and spending reports for multiple funded projects.
Coordinate with central teams on contracting, cost transfers, salary allocations, and grant closeouts.
Ensure financial compliance with NIH, federal, sponsor, and institutional guidelines.
Provide leadership with financial dashboards and projections to guide decision-making and ensure appropriate use of project resources according to project goals, timelines, and milestones.
Review costs and lead cost-reduction efforts to ensure financial sustainability and compliance.

3. Strategic Infrastructure Development

Develop onboarding curricula and training workflows to standardize research staff preparation across the lab and division.
Design and implement research management systems, workflows, and templates that improve operational efficiency, compliance, and reporting (e.g., protocol activation workflows, IRB submission checklists, REDCap dashboards, budget development worksheets, and standardized PI/funder report templates).
Create infrastructure that can be shared across the division, supporting other PIs and their teams through scalable tools.

4. Communications & Visibility

Oversee the development of internal and external communications (including newsletters, reports, social media, and outreach materials) with execution support from administrative staff and MGB communications/development offices.
Promote the visibility of the division, locally and globally, among academic and commercial partners, funding agencies, philanthropic supporters, and the broader public.
Coordinate with MGB communications and development offices to align messaging and maximize impact.

Additional Job Details (if applicable)

Required

Degree in life sciences, public health, healthcare administration, or related field
5+ years of progressive experience in human research operations (clinical trials, regulatory compliance, research administration).
Demonstrated ability to oversee protocol compliance, IRB processes, and Good Clinical Practice (GCP)standards.
Experience with study management systems (OnCore, REDCap, or equivalent).
Experience with pre- and post-award financial administration (e.g., grants administration, budget preparation, effort reporting, financial oversight and compliance).
Strong leadership, organizational, and communication skills, with the ability to manage complex projects and mentor staff.

Preferred

Project Management Professional (PMP) or equivalent certification.
Experience working in academic medical centers or large research organizations
Familiarity with Mass General Brigham systems and NIH funding mechanisms.
Certified Research Administrator (CRA) or equivalent credential.

Why Join Us?

Opportunity to serve as the primary operational leader for a large and innovative research team with direct capacity to shape the mission.
Build infrastructure and systems that will have an impact across the entire division.
Collaborate with world-class faculty and researchers at Mass General Brigham.
Enjoy strong institutional support, including dedicated pre- and post-award research management teams.
This position requires onsite presence at Mass General Brigham, with some flexibility for remote work (e.g., 1 or 2 days per week) depending on operational needs.
Competitive compensation and benefits package.

Remote Type

Hybrid

Work Location

149 Thirteenth Street Building 149

Scheduled Weekly Hours

Employee Type

Regular

Work Shift

Day (United States of America)

Pay Range

$97,510.40 - $141,804.00/Annual

Grade

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

EEO Statement:

Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Senior Program Manager

Benefits

Job Description