Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Reporting to the Senior Vice President, Head of Europe, the Vice President General Manager, UK and Ireland will lead the expansion efforts across UK and Ireland. In a highly competitive environment, this leadership role is critical to maximizing the opportunity of RevMed innovation to impact patients in UK and Ireland. In collaboration with the European LT, the successful leader will develop and execute commercialization and operational strategy to engage with key stakeholders (government authorities, regulatory authorities, payer authorities, KOLs) to help secure reimbursement that reflects the value of the innovation. The role will also play a key role in engaging other key constituencies to support expansion into the European region - ensuring that reimbursement and access considerations are integrated in the existing and future clinical program design of the RevMed portfolio / pipeline. The incumbent will be responsible for developing pre-launch and commercialization strategic plans for UK and Ireland and providing UK and Ireland-specific input into lifecycle plans across the RevMed portfolio. This individual will have full accountability for the UK and Ireland P&L, all market operations and will ensure official, fiduciary, and legal and compliance requirements are met locally and for the European region respectively.

Responsibilities:

Develop and manage the UK and Ireland P&L including the budget for market operations, ensuring optimal resource allocation with appropriate investment gating to key events/triggers.
Develop and execute comprehensive plans for the company’s expansion in UK & Ireland.
As dictated by the commercialization strategy, build and lead the required multifunctional management team, working with corporate functional leaders to ensure that each team member and business function execute against the clear and well-aligned business objectives.
Provide UK and Ireland input for Regional and Global Clinical Development Plans and Non-Registrational data generation plans.
Support the Clin Ops team by ensuring appropriate UK & Ireland site selection, quality and enrollment in-line with regulatory/compliance requirements.
Co-lead with Finance, Legal, and Commercial, the selection and contract negotiation with any local Distributor and Trade 3^rd parties and upon completion of contract, oversee and be accountable for successful execution and achievement of goals by the distributor.
Support the effective negotiation of consultant/agency contracts for timely and cost-effective services in various business areas to support pre-launch and launch activities.
Lead the UK and Ireland Government/Corporate Affairs efforts ensuring the successful execution of global and European strategies, advocating for policies that promote patient access in UK and Ireland. Cultivate and maintain strategic relationships with government entities, patient organizations, healthcare providers, industry associations, and medical societies through innovative engagement programs.
Represent the company in UK and Ireland healthcare policy forums and industry associations, collaborate with peers to shape collective positions and advocate for patient centered policies.
Support all relevant efforts to ensure the regional and global clinical program designs are informed by the UK and Ireland clinical and local/regional market access strategy and dynamics.
Work closely with regulatory affairs to secure best and fastest pathways to approvals.
Evaluate the competitive environment and understand the profile of portfolio compounds and the patients to serve to identify opportunities and challenges in the oncology market across Europe and other key markets.
Lead the planning and execution of product launches in UK and Ireland, including market access strategies, pricing, disease area and marketing campaigns, and where appropriate, early access programs.
Foster a culture with the global team consistent with the global RevMed values and vision/mission.
Set key launch and financial performance metrics including revenue, profitability etc.

Required Skills, Experience and Education:

Advanced degree in life sciences, business administration, or a related field.
Proven UK and Ireland experience in a leadership role within the biopharmaceutical industry.
Fluency in both verbal and written English; any other major European language is an advantage.
Proven track record shaping and executing regional strategy and influencing policy at a senior industry level.
In-depth knowledge of the UK and Ireland pharmaceutical market and regulatory environment.
Oncology, including NSCLC and pancreatic cancer and colorectal cancer related experiences as well as for biomarker/companion diagnostics.
Proven experience building and developing a high performing cross-functional team is a must.
Organizational and P&L Leadership experience in UK and Ireland required.
Ability to create and nurture a strong culture of collaboration and authenticity to extend and replicate the RevMed culture.
Proven success in building effective relationships with internal stakeholders, regional authorities, and vendors.
Highly organized and motivated individual possessing excellent communication, presentation and interpersonal skills.
Strong leadership and influencing skills with the ability to create a clear sense of direction.
Thrives in a fast-paced, dynamic small company environment and able to roll out the sleeves to get things done.

Preferred Skills:

Experience with an oncology launch in UK and Ireland is desired.
Serve as business partners to Development functions
Project Management experience and certification preferred.

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Vice President, General Manager, UK & Ireland

Job Description